Born in 1990 in Mexico City, his first role was in the soap opera El derecho de nacer (The right to be born, 2000). A year later, he acted in the Mexican film Zurdo (Left-handed, 2003), directed by Carlos Salces. In 2004, he starred in Temporada de patos (Duck Season), the first feature of Mexican director Fernando Eimbcke. For his performance in this film Diego Cataño was nominated as Best Actor at the 2005 MTV Movie Awards.
His next work was as the main character of the short film Ver llover (Watching it rain, 2006), directed by Elisa Miller, which won the Golden Palm and Norman McLaren Award for Best Short Film at the 2007 Cannes Film Festival, as well as the Short Film Competition Award at the 2006 Morelia International Film Festival. In 2006, he starred in Año uña (The year of the nail), the first feature of director Jonás Cuarón, which premiered at the XXII Guadalajara International Film Festival. He also participated in the first feature of director Rodrigo Plá, La zona (The zone, 2007) and had the main role in Mr. Pla’s second feature, Desierto adentro (Desert inside, 2008).