Jenkins burst onto the Canadian film scene with her charismatic acting and singing performance in Anne Wheeler's Bye Bye Blues, for which she received a Best Actress Genie Award. Her feature films include Interstate 60, Bob Roberts, Darrow, Marion Bridge, South of Wawa, and Cowboys Don't Cry, Daniel McIvor's films Past Perfect, A Whole New Thing and Wilby Wonderful.
Jenkins' many starring roles in movies for television include Stephen King's Kingdom Hosptital, The Five People You Meet in Heaven, Supervolvano, Into The West, 10.5, a guest role on the WB's Supernatural CBS's And Never Let Her Go, Guilty Hearts, Catch A Falling Star; Disney's Angels in the Infield; ABC's The Ruby Silver; and NBC's Bad Prospects, Till Death Do Us Part, Honour Bright and Harvest, for which she received a Gemini Award nomination as Best Supporting Actress in a Dramatic Program or Mini-Series.
On television, Jenkins is well known for her starring roles in CBC and Alliance's successful series Black Harbour, and in Atlantis's Destiny Ridge. She recently guest-starred on A&E's Nero Wolfe, CTV's The Associates, and most recently the Canadian TV series Godiva's.
As a singer, Jenkins toured with Parachute Club and Jane Siberry, and continues to perform on occasion, as in the recent tribute to Joni Mitchell. A song written by Jenkins appears in the film Wilby Wonderful.