In 1988, Kilik began his partnership with Spike Lee and has gone on to produce 11 of Lee's films, including Do the Right Thing, Mo' Better Blues, Jungle Fever, Malcolm X, Crooklyn, Clockers, Girl 6, He Got Game, Summer of Sam, Bamboozled, and most recently, 25th Hour.
Kilik produced Robert De Niro's highly acclaimed directorial debut, A Bronx Tale, based on the play by Chazz Palminteri. In 1995, Kilik produced Tim Robbins' Academy Award winner Dead Man Walking, based on Sister Helen Prejean's account of her work with Louisiana death row inmates, starring Susan Sarandon and Sean Penn. He also produced Julian Schnabel's directorial debut, Basquiat, starring Jeffrey Wright as Jean-Michel Basquiat and David Bowie as Andy Warhol. Next, he teamed with Gary Ross and Steven Soderbergh to produce Ross' directorial debut, Pleasantville, featuring Tobey Maguire and Reese Witherspoon. He produced Tim Robbins' Cradle Will Rock, the sweeping account of the many worlds that collided in New York City in 1937 while Orson Welles mounted his most challenging Broadway production.
In 2001 Kilik produced Julian Schnabel's Before Night Falls, based on the autobiography of Cuban writer Reinaldo Arenas, starring Javier Bardem, winner of the Best Actor award at the Venice Film Festival, the Independent Spirit Awards and the National Board of Review. Kilik also produced Ed Harris' directorial debut, Pollock, starring Harris as American painter Jackson Pollock and Marcia Gay Harden, who won the Oscar for Best Supporting Actress as Lee Krasner. Kilik produced Skins, directed by noted Native American filmmaker Chris Eyre, starring Graham Greene and filmed on the Pine Ridge Reservation.